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No TAM-DNA adducts were produced using human N -acetyltransferase I and II. HST antibody inhibited approximately 90% of TAM-DNA adduct formation generated by the cytosol or HST, suggesting that HST is primarily involved in the formation of TAM-DNA adducts. A novel software has been created to comprehensively characterize covalent modifications of DNA through mass spectral analysis of enzymatically hydrolyzed DNA using the neutral loss of 2′-deoxyribose, a nearly universal MS2 fragmentation process of protonated 2′-deoxyribonucleosides. These covalent modifications termed DNA adducts form through xenobiotic exposures or by reaction with CONCLUSIONS: The level of aromatic adducts in the DNA is independently associated with an increased risk of gastric and CRCs. This effect could be due to aromatic compounds present in tobacco smoke or formed in meat, but they could be also due to genotoxic compounds from other sources. COMPUTATIONAL STUDIES OF DAMAGED DNA: AN INVESTIGATION OF DNA O-LINKED ADDUCTS FORMED DUE TO EXPOSURE TO PHENOLIC CARCINOGENS MOHADESEH MAJDI YAZDI B.Sc., Sharif University of Technology, 2004 M.Sc., Tarbiat Modares University, 2008 A Thesis Submitted to the School of Graduate Studies of the University of Lethbridge in Partial Fulfillment of the We have demonstrated in the present paper that DNA bending and unwinding due to the major adduct formed by cisplatin are flanking-base independent so that factors other than prebent and/or unwound target must be responsible for the effect of sequence context on the affinity of platinated DNA-binding proteins to 1,2-GG intrastrand CL of cisplatin. Of the DNA adducts formed by tobacco carcinogens, exocyclic adducts have been extensively studied for their chemistry of formation [34, 99].

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This article has not been copyedited and formatted. DNA adducts in many human tissues [12]. In 2012, Phillips updated this topic and reviewed studies on tobacco smoke-related DNA adducts published since 2002 [10]. That review covered the chemical nature and origins of smoking-related DNA adducts and the effect of DNA repair and gene polymorphisms on the levels of DNA adducts in humans. Bulky chemical DNA adducts are formed when a reactive electrophilic carcinogen, formed by the metabolism of an indirect carcinogen, binds to a particular nucleophilic moiety in DNA. Nucleophilic targets of the reactive carcinogen include nitrogen and oxygen atoms within the bases and phosphodiester backbone of DNA. Department: Biovetenskaper och näringslära / Biosciences and Nutrition Biovetenskaper och näringslära / Biosciences and Nutrition These agents have the potential to modify the structure of an individual’s DNA, forming a wide variety of types of DNA damage, known as adducts. Some of these adducts are stressor-specific, such as those formed by the UV in sunlight.

Modification of the anticancer drug tamoxifen to avoid - DiVA

för västgötalitteratur, [2004. (sammanfattning) Lund : Univ., 2004 ISBN 91-628-6222-7 Lagerroth, Erland, 1925 Bortom Darwin och DNA : en growth factor-system and health related variables in the offspring : studies in women, Kristiansson, Monica, 1973 Protein adducts of hexahydrophthalic anhydride  För att tillämpa ekosystemansatsen krävs ett politiskt initiativ där ett land tar på sig DNA adducts and histopatholigical lesions in perch (Perca fluviatilis) and  DNA adducts are covalent interactions between reactive carcinogen chemical species and DNA (usually genomic). Adducts can be characterized by several criteria, including molecular size.

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However, we cannot rule out that adducts at AT base pairs are not mutagenic in this study since TA102 has an active NER system that could be repairing any mutagenic adducts at AT base pairs. The two major AFB –DNA adducts are also formed1 in the pulmonary tract in ratios similar to those seen in hepatic tissues of AFB -treated animals 31 . In-wx 1 halation of AFB on rats for 20–120 min results in1 an increase in the amount of AFB –N7-Gua adduct 1 formed in DNA in a dose-dependent manner 31 .wx 2.4.

Indeed, the bulky substituent may improve the stability of (non-native) Hoogsteen pairs. BACKGROUND: Colorectal (CRC) and gastric cancer (GC) are associated with meat intake and tobacco smoke, maybe because of aromatic compounds occurring in tobacco smoking and formed during cooking meat. Activated metabolites of these compounds may bind to DNA forming bulky adducts. Adduct formation is the result of a covalent binding between reactive electrophilic substances and the nucleophilic sites in DNA and proteins. The ability of a chemical to bind to DNA, either directly or after metabolic activation, is taken as an evidence of mutagenic and carcinogenic potential. Quantitation of the specific pyridyloxobutyl DNA adducts in calf thymus DNA treated with a model pyridyloxobutylating agent, 4- (acetoxymethylnitrosamino)-1- (3-pyridyl)-1-butanone (NNKOAc, Scheme 1), demonstrates that HPB-releasing adducts are the major adducts present in pyridyloxobutylated DNA [ 46 Various platinum (II) complexes have been shown to form DNA adducts which decrease gel mobility of DNA fragments due to either stable curvature of the helix axis or increased isotropic flexibility (23, 25 – 30).
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Institutet offentligen försvaras i Sal This was done by characterizing the DNA adduct N1-(2-. Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the and the levels of biomarkers related to exposure to aromatic compounds is highly relevant.

The These covalent adducts are formed by linking the 3, 4 or 4', 5’ edge of psoralen to the 5, 6 double bond of thymine. Psoralens can form two types of monoadducts and one diadduct (an interstrand crosslink) with thymine.
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instructions in the form of DNA or RNA, which are then introduced to the cell by  av J Montelius · 2009 · Citerat av 8 — Föreliggande dokument har tagits fram av Kriteriegruppen för hygieniska occupational exposure to PAH through analysis of DNA adducts in human Steinbeck G, Plato N, Alfredsson L, Norell S. Industry-related urothelial carcinogens:. Hallgard, Elna (författare); Modifying Cooking Practices to Reduce the Formation of Heterocyclic Amines; 2004; Doktorsavhandling (övrigt vetenskapligt)abstract. affecting agents, we do not know whether the effect is due to confounding. A positive hydrocarbon exposure, urinary mutagenicity, and DNA adducts in rubber  Degradation Mechanism of Silver Metal Deposited on Lead Halide Perovskites Perovskites with Narrow Band Gap via Lewis Acid-Base Adduct Approach Direct Determination of Metal Complexes' Interaction with DNA by Atomic Telemetry  Institutionaliseret etik har typisk form af universelle standarder, som. This is related to the medical industry and the growing presence of intense competition, In this study, we identified and characterized the disrupted gene in a T-DNA First Evidence for the Formation of a CO Cluster Adduct before CO Insertion. toxicokinetics due to co-exposure to methyl ethyl ketone (MEK) in volunteers. oxide in blood, hemoglobin adducts, and urinary metabolites in Walles SAS, Edling C, Anundi H, Johanson G. Exposure dependent increase in DNA single strand breaks Institutet för Miljömedicin, Karolinska Institutet.